Fighting Viruses

How Do Antivirals Work?

Antivirals are medications used specifically to treat viral infections. They aim to minimize the symptoms of an infection and shorten its duration. They also can help reduce transmission of a virus.

Rather than killing a virus directly, antivirals usually suppress the virus’s ability to infect and multiply in your cells. These drugs often work by inhibiting molecular interactions and functions needed by the virus to produce new copies of itself.

The way a drug produces its therapeutic effect is called its mechanism of action. Antivirals are often delivered in combinations that have different mechanisms of action. This helps to prevent the emergence of mutated drug-resistant viral strains that can bypass the effects of a single drug. For example, combination antiviral therapy is now the standard of care in HIV and hepatitis C virus infections. It is highly desirable to develop multiple antivirals whenever possible.

Is there an antiviral treatment for COVID-19?

Currently, antiviral therapy is available only for a limited number of infections, including those caused by HIV, herpes, hepatitis B and C, and influenza A and B. Drug companies and researchers are investigating new and existing antivirals, including Gilead’s remdesivir, for potential use in treating COVID-19, the disease caused by the novel coronavirus.

The development of antivirals can be challenging. Because viruses are parasites that hijack host cell machinery, care must be taken to select drug targets that interfere with viral replication while causing as little harm to healthy host cells as possible. Like vaccines, antivirals must go through a multistep approval process by the U.S. Food and Drug Administration (FDA).

Reference: Caltech Science Exchange

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